Anticancer studies on methanolic extract of aerial parts of Uraria Picta (Jacq.) DC

Abstract Background Uraria picta ( Jacq. ) DC is a traditional Indian herb used in the Ayurvedic system of medicine. It an ingredient popular formulation “Dasamoola.” also traditionally as anti-inflammatory Ayurveda. The plant has excellent antioxidant potential. Different parts are useful and have diverse medicinal properties. present investigation was done to evaluate anticancer activity methanolic extract aerial ). Results Preliminary phytochemical screening MEUP confirmed presence flavonoids, phenolics, glycosides, tannins. Total phenolic flavonoid contents were found be 14.6 gram equivalent gallic acid 0.735 catechin, respectively. IC50 values cisplatin 8.75 μg/ml 436.92 μg/ml, Induction apoptosis evident from DAPI staining showing dose-dependent increase apoptosis. Also, reduction intracellular ROS DCFH-da assay, where decrease (fluorescence) observed. Significant P < 0.05) tumor volume observed mice receiving at both dose levels. Conclusion effective inhibiting growth significant property.